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- Title
The Obesity Amelioration Effect in High-Fat-Diet Fed Mice of a Homogeneous Polysaccharide from Codonopsis pilosula.
- Authors
Su, Qi; Huo, Jiangyan; Wang, Yibin; Zhou, Yang; Luo, Dan; Hou, Jinjun; Zhang, Zijia; Long, Huali; Zhong, Xianchun; Xie, Cen; Lei, Min; Liu, Yameng; Wu, Wanying
- Abstract
A homogeneous polysaccharide coded as CPP−1 was extracted and purified from the root of Codonopsis pilosula (Franch.) Nannf. by water extraction, ethanol precipitation, and column chromatography. Its structure was analyzed by HPGPC-ELSD, HPLC, GC-MS, FT-IR, and NMR techniques. The results indicated that CPP−1 was composed of mannose (Man), glucose (Glc), galactose (Gal), and arabinose (Ara) at a molar ratio of 5.86 : 51.69 : 34.34 : 8.08. The methylation analysis revealed that the main glycosidic linkage types of CPP−1 were (1→)-linked-Glc residue, (1→3)-linked-Glc residues, (1→4)-linked-Gal residue, (1→2,3,4)-linked-Glc residue, (1→)-linked-Man residue, (1→3,4)-linked-Glc residue, and (1→)-linked-Ara residue. In vivo efficacy trial illustrated that CPP−1 supplements could alleviate HFD-induced mice obesity significantly, as well as improve obesity-induced disorders of glucose metabolism, alleviate insulin resistance, and improve the effects of lipid metabolism. The findings indicate that this polysaccharide has the potential for the treatment of obesity.
- Subjects
METABOLIC disorders; COLUMN chromatography; OBESITY; MICROBIAL exopolysaccharides; INSULIN; INSULIN resistance; LIPID metabolism; POLYSACCHARIDES
- Publication
Molecules, 2022, Vol 27, Issue 16, p5348
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27165348