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- Title
Organocatalytic Asymmetric [2 + 4] Cycloadditions of 3-Vinylindoles with ortho -Quinone Methides.
- Authors
Liu, Si-Jia; Tu, Man-Su; Liu, Kai-Yue; Chen, Jia-Yi; Ni, Shao-Fei; Zhang, Yu-Chen; Shi, Feng
- Abstract
Catalytic asymmetric [2 + 4] cycloadditions of 3-vinylindoles with ortho-quinone methides and their precursors were carried out in the presence of chiral phosphoric acid to afford a series of indole-containing chroman derivatives with structural diversity in overall high yields (up to 98%), good diastereoselectivities (up to 93:7 dr) and moderate to excellent enantioselectivities (up to 98% ee). This approach not only enriches the chemistry of catalytic asymmetric cycloadditions involving 3-vinylindoles but is also useful for synthesizing chiral chroman derivatives.
- Subjects
CHROMANS; PHOSPHORIC acid; RING formation (Chemistry)
- Publication
Molecules, 2021, Vol 26, Issue 21, p6751
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26216751