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- Title
Chiral Separation of the Phenylglycinol Enantiomers by Stripping Crystallization.
- Authors
Shiau, Lie-Ding; Tiritan, Maria Elizabeth; Pinto, Madalena; Fernandes, Carla Sofia Garcia
- Abstract
Stripping crystallization (SC) is introduced in this work for chiral purification of R-phenylglycinol from the enantiomer mixture with an initial concentration ranging from 0.90 to 0.97. As opposed to the solid–liquid transformation in melt crystallization, the three-phase transformation occurs in SC at low pressures during the cooling process. SC combines melt crystallization and vaporization to produce a crystalline product and mixture vapor from a mixture melt due to the three-phase transformation. Thermodynamic calculations were applied to determine the operating pressure for the three-phase transformation during the cooling process in the SC experiments. To consider the possible deviations between the calculated and the actual three-phase transformation conditions, the product purity and the recovery ratio of R-phenylglycinol were investigated within a range of operating pressures during the cooling process.
- Subjects
PHENYLGLYCINE; CRYSTALLIZATION; THERMODYNAMIC cycles; MOLECULAR dynamics; BIOACTIVE compounds
- Publication
Molecules, 2018, Vol 23, Issue 11, p2901
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules23112901