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- Title
A New Monoterpene from the Leaves of a Radiation Mutant Cultivar of Perilla frutescens var. crispa with Inhibitory Activity on LPS-Induced NO Production.
- Authors
Bomi Nam; Yangkang So; Hyo-Young Kim; Jin-Baek Kim; Chang Hyun Jin; Ah-Reum Han
- Abstract
The leaves of Perilla frutescens var. crispa (Lamiaceae)--known as 'Jureum-soyeop' or 'Cha-jo-ki' in Korean, 'ZI SU YE' in Chinese, and 'Shiso' in Japan--has been used as a medicinal herb. Recent gamma irradiated mutation breeding on P. frutescens var. crispa in our research group resulted in the development of a new perilla cultivar, P. frutescens var. crispa (cv. Antisperill; PFCA), which has a higher content of isoegomaketone. The leaves of PFCA were extracted by supercritical carbon dioxide (SC-CO2) extraction, and phytochemical investigation on this extract led to the isolation and identification of a new compound, 9-hydroxy-isoegomaketone [(2E)-1-(3-furanyl)-4-hydroxy-4-methyl-2-penten-1-one; 1]. Compound 1 exhibited inhibitory activity on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW264.7 cells with an IC50 value of 14.4 μM. The compounds in the SC-CO2 extracts of the radiation mutant cultivar and the original plant were quantified by high-performance liquid chromatography with diode array detection.
- Subjects
HERBAL medicine; PERILLA frutescens; RADIATION; CARBON dioxide; NITRIC oxide
- Publication
Molecules, 2017, Vol 22, Issue 9, p1471
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22091471