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- Title
Anti-Inflammatory Activity of Different Agave Plants and the Compound Cantalasaponin-1.
- Authors
Monterrosas-Brisson, Nayeli; Arenas Ocampo, Martha L.; Jiménez-Ferrer, Enrique; Jiménez-Aparicio, Antonio R.; Zamilpa, Alejandro; Gonzalez-Cortazar, Manases; Tortoriello, Jaime; Herrera-Ruiz, Maribel
- Abstract
Species of the agave genus, such as Agave tequilana, Agave angustifolia and Agave americana are used in Mexican traditional medicine to treat inflammation-associated conditions. These plants' leaves contain saponin compounds which show anti-inflammatory properties in different models. The goal of this investigation was to evaluate the anti-inflammatory capacity of these plants, identify which is the most active, and isolate the active compound by a bio-directed fractionation using the ear edema induced in mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) technique. A dose of 6 mg/ear of acetone extract from the three agave species induced anti-inflammatory effects, however, the one from A. americana proved to be the most active. Different fractions of this species showed biological activity. Finally the F5 fraction at 2.0 mg/ear induced an inhibition of 85.6%. We identified one compound in this fraction as (25R)-5α-spirostan-3β,6α,23α-triol- 3,6-di-O-β-D-glucopyranoside (cantalasaponin-1) through ¹H- and 13C-NMR spectral analysis and two dimensional experiments like DEPT NMR, COSY, HSQC and HMBC. This steroidal glycoside showed a dose dependent effect of up to 90% of ear edema inhibition at the highest dose of 1.5 mg/ear.
- Subjects
ANTI-inflammatory agents; INFLAMMATION treatment; TRADITIONAL medicine; SAPONINS; LABORATORY mice; GLUCOPYRANOSIDE
- Publication
Molecules, 2013, Vol 18, Issue 7, p8136
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules18078136