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- Title
Synthesis and Antitumor Evaluation of 6-Aryl-substituted benzo[j]phenanthridine- and Benzo[g]pyrimido[4,5-c]isoquinolinequinones.
- Authors
Iribarra, Jennyfer; Vásquez, David; Theoduloz, Cristina; Benites, Julio; Ríos, David; Valderrama, Jaime A.
- Abstract
A variety of novel 6-arylsubstituted benzo[j]phenanthridine- and benzo[g]- pyrimido[4,5-c]isoquinolinequinones were synthesized from 1,4-naphthoquinone, arylaldehydes and enaminones via a two-step synthetic approach. The cytotoxic activity of the aminoquinone derivatives was evaluated in vitro against one normal cell line (MRC-5 lung fibroblasts) and three human cancer cell lines (AGS human gastric adenocarcinoma; SK-MES-1 human lung cancer cells, and J82 human bladder carcinoma) in 72-h drug exposure assays using the MTT colorimetric method. Structure-activity relationships within the series of angular quinones reveal that the insertion of pyrrol-2-yl and furan-2-yl groups at the 6-position is more significant for the increase of the potency and selectivity index of the pharmacophores.
- Subjects
BENZOATES; CHEMICAL synthesis; PHENANTHRIDINE; CELL-mediated cytotoxicity; CELL lines; LUNG cancer prevention; CANCER cells
- Publication
Molecules, 2012, Vol 17, Issue 10, p11616
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules171011616