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- Title
Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives.
- Authors
Pertino, Mariano Walter; Theoduloz, Cristina; Palenzuela, Jose Antonio; Afonso, Maria del Mar; Yesilada, Erdem; Monsalve, Francisco; González, Paulo; Droguett, Daniel; Schmeda-Hirschmann, Guillermo
- Abstract
New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human cell lines: Normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2). Several of the new compounds were significantly active as antiulcer agents and showed selective cytotoxicity against AGS cells.
- Subjects
DITERPENES; NAPHTHOQUINONE; LABORATORY mice; CELL lines; LIVER cancer; ANTIULCER drugs
- Publication
Molecules, 2011, Vol 16, Issue 10, p8614
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules16108614