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- Title
Sequence analysis of a feline- and porcine-origin G3P[9] rotavirus A strain in a child with acute gastroenteritis in Japan.
- Authors
Fukuda, Yuya; Araki, Kaoru; Hara, Megumi; Yamashita, Yuji; Adachi, Shuhei; Honjo, Saho; Togashi, Atsuo; Hirakawa, Satoshi; Fukumura, Shinobu; Yamamoto, Masaki; Tsugawa, Takeshi
- Abstract
We isolated the rare G3P[9] rotavirus strain RVA/Human-wt/JPN/R11-035/2015/G3P[9] from a 2-year-old girl presenting with vomiting and diarrhea who had daily contact with cats in Japan, 2015. Full-genome analysis revealed that the R11-035 strain had an AU-1-like genetic constellation, except for the NSP3 (T) gene: G3-P[9]-I3-R3-C3-M3-A3-N3-T1-E3-H6. Phylogenetic analysis showed that strain R11-035 is closely related to human/feline-like human strains, and only the NSP3 (T1) gene was clustered together with Taiwanese porcine strains. We postulate that the R11-035 strain was directly transmitted from a cat to the patient and acquired its NSP3 gene through intergenotype reassortment with porcine strains before being transmitted to humans.
- Subjects
JAPAN; ROTAVIRUS diseases; SEQUENCE analysis; GASTROENTERITIS; ROTAVIRUSES; GENE clusters; CATS
- Publication
Archives of Virology, 2023, Vol 168, Issue 2, p1
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-022-05685-3