We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Activity of Proline-Specific Peptidases in Brain Structures of Rats with Experimental MPTP-Induced Depressive Syndrome.
- Authors
Khlebnikova, N.; Krupina, N.; Bogdanova, N.; Zolotov, N.
- Abstract
A noncompetitive synthetic inhibitor of prolyl endopeptidase benzyloxycarbonyl-methionyl- 2(S)-cyanopyrrolidine (1.0 mg/kg intraperitoneally for 2 weeks) prevented the increase in activity of prolyl endopeptidase in the frontal cortex, striatum, and hypothalamus and activation of dipeptidyl peptidase IV in the frontal cortex of rats with experimental dopamine deficiency-dependent depressive syndrome caused by administration of proneurotoxin MPTP (2 weeks). Our results suggest that the antidepressive effect of prolyl endopeptidase inhibitor is at least partly related to prevention of enzyme activation in the frontal cortex. The antistress effect of this substance can be associated with prevention of enzyme activation in the hypothalamus.
- Subjects
ENDOPEPTIDASES; CHEMICAL inhibitors; PYRROLIDINE; PROLINE; BRAIN anatomy; MENTAL depression; LABORATORY rats
- Publication
Bulletin of Experimental Biology & Medicine, 2013, Vol 155, Issue 6, p711
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-013-2233-y