We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparison of inter- and intra-cycle variability of anti-Mullerian hormone and antral follicle counts.
- Authors
van Disseldorp, J.; Lambalk, C. B.; Kwee, J.; Looman, C. W. N.; Eijkemans, M. J. C.; Fauser, B. C.; Broekmans, F. J.
- Abstract
<bold>Background: </bold>The antral follicle count (AFC) and anti-Müllerian hormone (AMH) both represent age-related follicular decline quite accurately, although long-term follow-up studies are still lacking. The best ovarian reserve test would need only a single, cycle-independent measurement to be representative.<bold>Methods: </bold>To compare the inter- and intra-cycle stability of AFC and AMH, we used age-adjusted intra-class correlation coefficients (ICCs). To measure inter-cycle stability across a number of up to four menstrual cycles, we used data, prospectively collected for the purpose of an other study, from 77 regularly cycling, infertile women aged 24-40 years. AMH and AFC values were measured on cycle day 3. To study intra-cycle variability, we used data from a prospective cohort study of 44 regularly cycling volunteers, aged 25-46 years and measured AMH and assessed the AFC (2-10 mm) every 1-3 cycle days.<bold>Results: </bold>Between menstrual cycles, AFC and AMH varied between 0 and 25 follicles (median 10), and 0.3 and 27.1 ng/ml (median 4.64). The difference in age-adjusted ICC between AMH [ICC, 0.89 (95% CI, 0.84-0.94)] and AFC [ICC, 0.71 (95% CI, 0.63-0.77)] was 0.18 (95% CI, 0.12-0.27). For the intra-cycle variation, 0-43 antral follicles (median 7) were counted per volunteer. The difference in age-adjusted ICC between AMH [ICC, 0.87 (95% CI, 0.82-0.91)] and AFC [ICC, 0.69 (95% CI, 0.46-0.82)] was 0.18 (95% CI, 0.034-0.42).<bold>Conclusions: </bold>Serum AMH demonstrated less individual intra- and inter-cycle variation than AFCs and may therefore be considered a more reliable and robust means of assessing ovarian reserve in subfertile women.
- Subjects
ANTRAL-oral fistula; ESTRONE; HORMONES; MENSTRUAL cycle; SERUM
- Publication
Human Reproduction, 2010, Vol 25, Issue 1, p221
- ISSN
0268-1161
- Publication type
journal article
- DOI
10.1093/humrep/dep366