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- Title
Role of allelic genes of matrix metalloproteinases and their tissue inhibitors in the risk of peptic ulcer disease development.
- Authors
Shaymardanova, E.; Nurgalieva, A.; Khidiyatova, I.; Gabbasova, L.; Kuramshina, O.; Kryukova, A.; Sagitov, R.; Munasipov, F.; Khusnutdinova, E.
- Abstract
Peptic ulcer disease is a chronic disease of the gastrointestinal tract, mainly manifesting itself in the formation of the fairly persistent ulcer defect of the mucous membrane of the stomach and/or duodenum. Association analysis of common polymorphisms of matrix metalloproteinases genes MMP-1 ( rs1799750, rs494379), MMP-2 ( rs2285052), MMP-3 ( rs3025058), MMP-9 ( rs3918242, rs17576), and MMP-12 ( rs2276109) and their tissue inhibitors TIMP-2 ( rs8179090) and TIMP-3 ( rs9619311) was carried out in 353 patients with a gastric ulcer or duodenal ulcer and in 325 unrelated healthy individuals from the Republic of Bashkortostan. Associations of polymorphic variants rs1799750 and rs494379 of gene MMP-1, rs3025058 of gene MMP-3, rs3918242 and rs17576 of gene MMP-9, and rs9619311 of gene TIMP-3 with the risk of peptic ulcer disease in Russians and Tatars were revealed.
- Subjects
PEPTIC ulcer; MATRIX metalloproteinases; TISSUE inhibitors of metalloproteinases; DUODENUM; GENETIC polymorphisms; ULCERS; DISEASE risk factors
- Publication
Russian Journal of Genetics, 2016, Vol 52, Issue 3, p320
- ISSN
1022-7954
- Publication type
Article
- DOI
10.1134/S1022795416020113