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- Title
An efficient one-pot synthesis of 3-aryl-5-(dialkoxymethyl)-1,2,4-oxadiazoles under solvent-free conditions.
- Authors
Adib, Mehdi; Saeedi, Sara; Soheilizad, Mehdi; Bayanati, Maryam; Tajbakhsh, Mahmood; Amanlou, Massoud
- Abstract
An efficient and simple synthesis of 3-aryl-5-(dialkoxymethyl)-1,2,4-oxadiazoles is described. The in situ prepared amidoximes from the reaction between nitriles and hydroxylamine are condensed with alkyl 2,2-dialkoxyacetates under solvent-free conditions to produce the title compounds in excellent yields.
- Subjects
OXADIAZOLES; HETEROCYCLIC compounds; NITRILE synthesis; HYDROXYLAMINE; ACETIC acid
- Publication
Journal of Chemical Research, 2016, Vol 40, Issue 5, p314
- ISSN
1747-5198
- Publication type
Article
- DOI
10.3184/174751916X14608135651135