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- Title
EFFECT OF BLACK GRAPE EXTRACT ON CD4+ and CD8<sup>+</sup> EXPRESSION IN MICE INFECTED WITH Salmonella typhimurium.
- Authors
Destiawan, Rian Anggia; Rahmawati, Septyana Eka; Wijaya, Anas Fadli; Muflihah, Ahdiah Imroatul; Hidayati, Sholihatil; Nurjanah, Mutia Hariani; Sari, Ni Ketut Yuliana
- Abstract
Salmonelosis is a disease caused by the Salmonella sp. that causes a decrease in CD4+ expression. Black grape can boost the immune system through CD4+/CD8+ proliferation. The purpose of this study was to evaluate the activity of black grape extract to CD4+ and CD8+ expression in mice infected with Salmonella typhimurium. Research method is extract of black grapes, Salmonella typhimurium 108 infection, bacterial evaluation, extract therapy, flowcytometery examination, and 95% Anova test. The results of Anova test showed that the expression of CD4+ and CD8+ is not different. Biologically, an increase in CD4+ and CD8+ expression at doses of 100 mg/KgBB. A decrease in CD4+ and CD8+ expression at doses of 200 mg/KgBB and 400 mg/KgBB. Conclusion, biologically, black grape extract can increase the expression of CD4+ and CD8+ at low doses, as well as may decrease the expression of CD4+ and CD8+ at moderate to high doses.
- Subjects
SALMONELLA typhimurium; GRAPES; FLOW cytometry; CD80 antigen; SALMONELLA diseases; CD4 antigen
- Publication
Jurnal Biosains Pascasarjana, 2022, Vol 24, p54
- ISSN
1412-1433
- Publication type
Article
- DOI
10.20473/jbp.v24i1SP.2022.54-63