We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Complement-Mediated Death of Ciliate Tetrahymena pyriformis Caused by Human Blood Serum.
- Authors
Ivanov, P.; Faktor, M.; Karpova, N.; Cheremnykh, E.; Brusov, O.
- Abstract
Toxicity of human blood serum for ciliate Tetrahymena pyriformis is determined by the complement system. When ciliate are dying after being exposed to blood serum, cell membrane permeability for low-molecular-weight compounds significantly increases, probably due to pore formation. Serine protease inhibitors or exposure to physical factors inducing complement inactivation ( e.g., heating up to 56°C) completely prevented ciliate death under the effect of human serum. Activation of serum complement upon interaction with Tetrahymena cells occurred by the classical or lectin pathway, while the contribution of the alternative activation pathway was negligible.
- Subjects
TETRAHYMENA pyriformis; BLOOD serum analysis; CELL membranes; MOLECULAR weights; SERINE proteinase inhibitors; BLOOD microbiology
- Publication
Bulletin of Experimental Biology & Medicine, 2016, Vol 160, Issue 6, p775
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-016-3307-4