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- Title
Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene.
- Authors
Maier, L.M.; Twells, R.C.J.; Howson, J.M.M.; Lam, A.C.; Clayton, D.G.; Smyth, D.J.; Savage, D.; Carson, D.; Patterson, C.C.; Smink, U.; Walker, N.M.; Burren, O.S.; Nutland, S.; Rance, H.; Tuomilehto-Wolf, E.; Tuomilehto, J.; Guja, C.; Ionescu-Tirgoviste, C.; Undlien, D.E.; Rønningen, K.S.
- Abstract
Variations in the interleukin 4 receptor A (IL4RA) gene have been reported to be associated with atopy, asthma, and allergy, which may occur less frequently in subjects with type 1 diabetes (T1D). Since atopy shows a humoral immune reactivity pattern, and T1D results from a cellular (T lymphocyte) response, we hypothesised that alleles predisposing to atopy could be protective for T1D and transmitted less often than the expected 50% from heterozygous parents to offspring with T1D. We genotyped seven exonic single nucleotide polymorphisms (SNPs) and the -3223 C>T SNP in the putative promoter region of IL4RA in up to 3475 T1D families, including 1244 Finnish T1D families. Only the -3223 C>T SNP showed evidence of negative association (P=0.014). There was some evidence for an interaction between -3233 C>T and the T1D locus IDDM2 in the insulin gene region (P=0.001 in the combined and P=0.02 in the Finnish data set). We, therefore, cannot rule out a genetic effect of IL4RA in T1D, but it is not a major one.Genes and Immunity (2003) 4, 469-475. doi:10.1038/sj.gene.6364007
- Subjects
INTERLEUKIN-4; NUCLEOTIDES; ASTHMA; ALLERGIES; DIABETES; HUMAN genetics
- Publication
Genes & Immunity, 2003, Vol 4, Issue 7, p469
- ISSN
1466-4879
- Publication type
Article
- DOI
10.1038/sj.gene.6364007