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- Title
Differential expression and functions of miRNAs in bladder cancer.
- Authors
Hao Huang; Xiaowu Pi; Chenqi Xin; Chen Gong; Feng Guo; Yang Wang; Ying Xiong
- Abstract
Bladder cancer (BC), a urologic disease, commonly occurs globally and is very invasive. Patients with invasive BC have low 5-year survival rate. Hence, the mechanisms underlying BC development and progression should be elucidated. MicroRNAs (miRNAs), as common noncoding RNAs, are receiving increasing attention because of their biological functions. The irregular expression patterns of miRNAs are linked to BC occurrence; therefore, determining the functions of miRNAs in abnormally expressed BC tissues might enable to elucidate the pathogenetic mechanism of BC and offer new markers for the prognosis, diagnosis, and therapy of BC. Here, we consolidate the primary roles of miRNAs with atypical expression in BC development as well as their association with BC pathological grades and chemotherapy resistance development in patients with BC.
- Subjects
GENE expression; BLADDER cancer; MICRORNA; NON-coding RNA; URINARY organ diseases
- Publication
Oncologie (De Gruyter), 2023, Vol 25, Issue 1, p1
- ISSN
1765-2839
- Publication type
Article
- DOI
10.1515/oncologie-2022-1030