We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
NANOPARTICULATE SYSTEMS FOR CONTROLLED PROPRANOLOL-HCL RELEASE: MODIFIED CORN STARCH APPROACH.
- Authors
Maradiya, Mohyuddin A.; Rami, Gaurang K.; Barot, Parth A.; Vora, Jabali J.
- Abstract
Modified starch nanoparticles present a promising avenue for developing new renewable and biodegradable nanomaterials for biomedical and pharmaceutical applications, especially when used as carriers for cardiovascular medicines in targeted drug delivery systems. The characteristics of these nanoparticles, crucial for controlled drug release applications, heavily depend on the synthesis method and conditions, aiming for a controlled and uniform size. This study focused on creating Propranolol HCl-loaded Butylated starch nanoparticles (SBPNPs) with minimal toxicity, employing the emulsion solvent evaporation technique along with ultrasonication. Propranolol HCl is a non-cardioselective drug that acts by competitively blocking catecholamines at β-adrenergic receptors, particularly affecting the heart, vessels and bronchi. The nanoparticles were analyzed using various techniques such as Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction analysis (XRD), Thermogravimetric analysis (TGA), Field emission scanning electron microscopy (FE-SEM) and Particle size analyzer to characterize them. The study also assessed the encapsulation efficiency and drug-release behaviour of these nanoparticles. The findings suggest that Butylated starch nanoparticles have potential as carriers for cardiovascular agents, providing controlled release capabilities and biocompatibility.
- Subjects
FOURIER transform infrared spectroscopy techniques; CORNSTARCH; TARGETED drug delivery; FIELD emission electron microscopy; CONTROLLED release drugs; DRUG delivery systems
- Publication
Biochemical & Cellular Archives, 2024, Vol 24, Issue 1, p1227
- ISSN
0972-5075
- Publication type
Article
- DOI
10.51470/bca.2024.24.1.1227