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- Title
Frontal Lobe Metabolic Decreases with Sleep Deprivation not Totally Reversed by Recovery Sleep.
- Authors
Wu, Joseph C.; Gillin, J. Christian; Buchsbaum, Monte S.; Chen, Phillip; Keator, David B.; Khosla Wu, Neetika; Darnall, Lynn A.; Fallon, James H.; Bunney, William E.
- Abstract
We studied the effects of total sleep deprivation and recovery sleep in normal subjects using position emission tomography with 18F-deoxyglycose. Sleep deprivation resulted in a significant decrease in relative metabolism of the frontal cortex, thalamus, and striatum. Recovery sleep was found to have only a partial restorative effect on frontal lobe function with minimal reversal of subcortical deficits. Sleep may be especially important for maintenance of frontal lobe activity.Neuropsychopharmacology (2006) 31, 2783–2792. doi:10.1038/sj.npp.1301166; published online 26 July 2006
- Subjects
SLEEP deprivation; PHYSIOLOGICAL stress; SLEEP; FRONTAL lobe; CEREBRAL cortex
- Publication
Neuropsychopharmacology, 2006, Vol 31, Issue 12, p2783
- ISSN
0893-133X
- Publication type
Article
- DOI
10.1038/sj.npp.1301166