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- Title
Impact of Prescription Medicines on Work-Related Outcomes in Workers with Musculoskeletal Disorders or Injuries: A Systematic Scoping Review.
- Authors
Tefera, Yonas Getaye; Gray, Shannon; Nielsen, Suzanne; Gelaw, Asmare; Collie, Alex
- Abstract
Purpose: Medicines are often prescribed to workers with musculoskeletal disorders (MSDs) and injuries to relieve pain and facilitate their recovery and return to work. However, there is a growing concern that prescription medicines may have adverse effects on work function. This scoping review aimed to summarize the existing empirical evidence on prescription medicine use by workers with MSD or injury and its relationship with work-related outcomes. Methods: We identified studies through structured searching of MEDLINE, EMBASE, PsycINFO, CINAHL Plus, Scopus, Web of Science and Cochrane library databases, and via searching of dissertations, theses, and grey literature databases. Studies that examined the association between prescription medicine and work-related outcomes in working age people with injury or MSDs, and were published in English after the year 2000 were eligible. Results: From the 4884 records identified, 65 studies were included for review. Back disorders and opioids were the most commonly studied musculoskeletal conditions and prescription medicines, respectively. Most studies showed a negative relationship between prescription medicines and work outcomes. Opioids, psychotropics and their combination were the most common medicines associated with adverse work outcomes. Opioid prescriptions with early initiation, long-term use, strong and/or high dose and extended pre- and post-operative use in workers' compensation setting were consistently associated with adverse work function. We found emerging but inconsistent evidence that skeletal muscle relaxants and non-steroidal anti-inflammatory drugs were associated with unfavorable work outcomes. Conclusion: Opioids and other prescription medicines might be associated with adverse work outcomes. However, the evidence is conflicting and there were relatively fewer studies on non-opioid medicines. Further studies with more robust design are required to enable more definitive exploration of causal relationships and settle inconsistent evidence.
- Subjects
MEDICAL information storage &; retrieval systems; NONSTEROIDAL anti-inflammatory agents; BENZODIAZEPINES; MUSCULOSKELETAL system diseases; CINAHL database; MUSCLE relaxants; TREATMENT effectiveness; BACK injuries; WORKERS' compensation; TRANQUILIZING drugs; WORK-related injuries; SYSTEMATIC reviews; MEDLINE; ANTIDEPRESSANTS; LITERATURE reviews; MEDICAL databases; OPIOID analgesics; DRUGS; POSTOPERATIVE period; INDUSTRIAL hygiene; PSYCHOLOGY information storage &; retrieval systems; PSYCHIATRIC drugs; LUMBAR pain
- Publication
Journal of Occupational Rehabilitation, 2024, Vol 34, Issue 2, p398
- ISSN
1053-0487
- Publication type
Article
- DOI
10.1007/s10926-023-10138-y