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- Title
Characteristic correlations of the structure-function relationship in different glaucomatous disc types.
- Authors
Omodaka, Kazuko; Takada, Naoko; Yamaguchi, Takuhiro; Takahashi, Hidetoshi; Araie, Makoto; Nakazawa, Toru
- Abstract
Purpose: To investigate the influence of the optic disc type on the overall and regional correlation between structure and function in open angle glaucoma (OAG). Methods: We divided 144 eyes of 144 patients with OAG into four groups according to Nicolela et al.'s classification of optic disc type: focal ischemic (FI), myopic glaucomatous (MY), senile sclerotic (SS), and generalized enlargement (GE). We measured the circumpapillary retinal nerve fiber layer thickness (cpRNFLT) with the 3D OCT-2000 and the mean deviation (MD) with the Humphrey Field Analyzer in each group and determined the influence of the disc type on these parameters with the Spearman rank correlation. Results: We found that cpRNFLT and MD were significantly correlated in the MY ( r = 0.61, P < 0.001), GE ( r = 0.62, P < 0.001), and SS groups ( r = 0.52, P = 0.002), but not in the FI group ( r = 0.25, P = 0.130). The region of the optic disc with the highest correlation coefficient between structure and function differed according to the disc type. Conclusions: The correlation between cpRNFLT and MD varied according to the optic disc morphology in OAG. This suggests that different disc types have characteristic regional variations in the correlation between structure and function. The disc type should therefore be considered in investigations of the correlation between structure and function in glaucoma.
- Subjects
OPTIC disc; GLAUCOMA; STATISTICAL correlation; OPTICAL coherence tomography; VISUAL field measurement
- Publication
Japanese Journal of Ophthalmology, 2015, Vol 59, Issue 4, p223
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-015-0379-z