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- Title
绝经后2 型糖尿病患者血清25(OH) D、Leptin 与骨代谢的相关性
- Authors
李琪; 陈先丹; 牟芝群; 阳琰; 王哲; 樊思桐; 刘贝贝
- Abstract
Objective To investigate the relationship between the levels of serum 25-hydroxyvitamin D(25(OH)D), leptin(LEP) and bone metabolism in postmenopausal women with type 2 diabetes. Methods A total of 130 postmenopausal women with T2 DM were selected from Affiliated Hospital of Zunyi Medical College. They were divided into normal bone mass group(group A, n=40), osteopenia group(group B, n=45) and osteoporosis group(C group, n=45) according to bone mineral density. At the same time, 50 healthy postmenopausal women were selected as the blank control group(group NC, n=50). Clinical data and biochemical indexes of all subjects were collected, serum 25(OH)D, LEP, degradation products of collagen beta(beta-Crosslaps, β-CTX), N-terminal propeptide of type I collagen(PINP) and osteocalcin(bone gla protein, BGP) levels were determined. Spearmen correlation analysis was used to analyze related factors of bone metabolism in patients with T2 DM and osteoporosis(OP) after menopause. Logistic regression analysis was used to analyze the influencing factors of OP in postmenopausal T2 DM patients. Results (1)Compared with the NC group, the levels of 25(OH)D and PINP in the A, B and C three groups decreased significantly, while LEP, beta-CTX and BGP levels increased significantly(P<0.05); (2)Compared with the A group, the levels of 25(OH)D and PINP in groups B and C decreased significantly, while the levels of LEP, beta-CTX and BGP increased significantly(P<0.05); (3)Compared with the B group, the levels of 25(OH)D and PINP in group C decreased obviously, but the levels of LEP, beta-CTX and BGP increased significantly(P<0.05). Spearmen correlation analysis showed that serum 25(OH)D positively correlated with PINP, negatively correlated with beta-CTX, and had no significant correlation with BGP. Serum LEP negatively correlated with PINP, but not related to beta-CTX and BGP. Logistic regression analysis showed that BMI, HbA1 c, 25(OH)D, LEP, PINP, and beta-CTX were independent risk factors for osteoporosis in postmenopausal women. Conclusion The decrease of serum levels of 25(OH)D and the increase of LEP levels may lead to osteoporosis in postmenopausal women with T2 DM.
- Publication
Chinese Journal of Osteoporosis, 2018, Vol 24, Issue 12, p1612
- ISSN
1006-7108
- Publication type
Article
- DOI
10.3969/j.issn.1006-7108.2018.12.011