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- Title
Expert consensus of clinical application of the bone metabolic and biochemical markers, by Osteoporosis Committee of Chinese Gerontological Society.
- Authors
ZHANG Mengmeng
- Abstract
The bone metabolic and biochemical markers include calcium and phosphorus metabolic indicators, bone resorption markers, and bone formation markers. The bone metabolic and biochemical markers are derived from the bone, cartilage, soft tissue, skin, liver, kidney, small intestine, blood, endocrine glands, etc. They are enzymes and hormones secreted by osteoblasts or osteoclasts, and the metabolic products of collagen or non-collagen proteins from bone matrix. The bone metabolic and biochemical markers reflect the status of bone turnover promptly, with high sensitivity and specificity. They have been used in osteoporosis diagnosis, prediction of fracture risk, curative effect observation of drug treatment, and the differential diagnosis of metabolic bone disease. They have important application value in the research of the pathogenesis of osteoporosis, drugs for treatment of osteoporosis, and the epidemiological study. The clinical use of the bone metabolic and biochemical markers is getting popular due to the mature of the detection technology. However, the test results vary because of different source of the specimen, different methods, different equipment, different reagents, different ages, different races, and different gender. So far, there is no unified detection standard of bone metabolic and biochemical markers in the world. Therefore, we collect and summarize the biological role and clinical significance of bone metabolic and biochemical markers, application technology, and quality control in this paper, in order to provide a readable, applicable, and well referred material to colleagues. We look forward to promoting the detection technology for bone metabolic and biochemical markers in clinic, standardizing detection process, and establishing scientific reference range through the consensus, so that the bone metabolic and biochemical markers can play an important role in the standardization of osteoporosis diagnosis and treatment, anti-osteoporosis drug efficacy evaluation, and scientific research.
- Subjects
OSTEOPOROSIS; BIOMARKERS; BONE resorption; METABOLIC bone disorders; OSTEOPOROSIS diagnosis; OSTEOPOROSIS treatment; GERONTOLOGY; SOCIETIES
- Publication
Chinese Journal of Osteoporosis, 2014, Vol 20, Issue 11, p1264
- ISSN
1006-7108
- Publication type
Article