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- Title
慢性牙周炎患者血清 CGRP、PGE2、CCL20 与牙周临床指标 和 Th17/Treg 失衡的相关性分析.
- Authors
刘昌玲; 陈耀武; 魏晓莹; 许展; 李少英; 张旭凤
- Abstract
Objective:To explore the correlation between serum calcitonin gene related peptide (CGRP),prostaglandin E2(PGE2),CC chemokine ligand 20 (CCL20) with periodontal clinical indicators and helper T lymphocyte 17/regulatory T lymphocyte (Th17/Treg)imbalance in patients with chronic periodontitis.Methods:91 patients with chronic periodontitis who were admitted to Hainan Women and Children Medical Center from May 2020 to May 2022 were selected,and they were divided into mild group (39 cases),moderate group(36 cases) and severe group (16 cases) according to their severity.Serum CGRP,PGE2,CCL20,periodontal clinical indicators[bleeding index(BI),probing depth(PD),attachment loss (AL),plaque index (PLI)],peripheral blood Th17 cell ratio,Treg cell ratio,and Th17/Treg ratio were compared in the three groups.Pearson correlation was used to analyze the correlation between serum CGRP,PGE2,CCL20and periodontal clinical indicators and Th17/Treg imbalance.Results:Compared with the mild group,the serum CGRP and Treg cells proportion in the moderate group and severe group were significantly decreased(P<0.05),and the serum PGE2,CCL20,BI,PD,PLI,AL,Th17 cells proportion and Th17/Treg ratio were significantly increased (P<0.05).Compared with the moderate group,the serum CGRP and Treg cells proportion in the severe group were significantly decreased (P<0.05),while the serum PGE2,CCL20,BI,PD,PLI,AL,Th17 cells proportion and Th17/Treg ratio were significantly increased (P<0.05).The correlation results showed that serum PGE2and CCL20 levels were positively correlated with the BI,PD,PLI,AL,Th17 cells proportion and Th17/Treg ratio (P<0.05),and negatively correlated with the Treg cells proportion (P<0.05).Serum CGRP level was negatively correlated with BI,PD,PLI,AL,the Th17 cells proportion and Th17/Treg ratio(P<0.05),and positively correlated with the Treg cells proportion (P<0.05).Conclusion:Serum CGRP,PGE2and CCL20 levels in patients with chronic periodontitis are significantly related to the severity of the disease,periodontal clinical indicators and Th17/Treg imbalance.Serum CGRP,PGE2and CCL20 may participate in the occurrence and development of chronic periodontitis by affecting the Th17/Treg balance.
- Subjects
HAINAN Sheng (China); CALCITONIN gene-related peptide; PERIODONTITIS; REGULATORY T cells; T helper cells; T cells; RATIO &; proportion
- Publication
Progress in Modern Biomedicine, 2023, Vol 23, Issue 14, p2745
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2023.14.028