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- Title
Phytochemical Screening and Pharmacological Activities of Echium judaeum Lacaita Extracts Growing Wild in Jordan.
- Authors
Al-Hamaideh, Khawla D.; El-Elimat, Tamam; Afifi, Fatma U.; Kasabri, Violet
- Abstract
Echium judaeum Lac. (Boraginaceae) growing wild in Jordan has not been studied before phytochemically and pharmacologically. In this study the hydro-alcoholic extract was analyzed using Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS). Total phenols and flavonoids were determined colorimetrically. Using SRB assay, the anti-proliferative effect against a panel of colorectal cancer cell lines (HT29, HCT116, SW620 and CACO2) was determined. Moreover anti- lipedimic and anti-obesity effects were examined, in addition to the determination of median lethal dose (LD50) of the aqueous extract. UPLC-MS analysis resulted in the identification of 6 compounds; luteolin, kaempferol, esculin, rosmarinic acid, echiumine and echimidine. LD50 was more than 3000mg/kg body weight. Neither anti-obesity nor anti-proliferative effects were detected. Since E. judaeum is a safe species and contains phenolic compounds, further pharmacological screening is recommended.
- Subjects
BORAGINACEAE; FLAVONOIDS; COLON cancer
- Publication
Jordan Journal of Pharmaceutical Sciences, 2017, Vol 10, Issue 3, p153
- ISSN
1995-7157
- Publication type
Article