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- Title
Anti-allergic effects of the brown alga Eisenia arborea on Brown Norway rats.
- Authors
SUGIURA, Yoshimasa; MATSUDA, Kohji; OKAMOTO, Takashi; KAKINUMA, Makoto; AMANO, Hideomi
- Abstract
To investigate the anti-allergic effects of the brown alga Eisenia arborea. A strain of Brown Norway rats known to strongly respond to immunoglobulin E (IgE) were used as an allergy model animal. The rats were immunized with ovalbumin by oral administration. The levels of serum IgE and histamine were suppressed in the rats fed a diet supplemented with dried E. arborea powder. As for the cytokine pattern, the interferon-γ production in the spleens and mesenteric lymph nodes (MLN) was enhanced, and the interleukin-4 (IL-4) production in the spleens and/or IL-10 production in the spleens and MLN were suppressed. These results, together with the change in the Th1/Th2 balance, indicate that the rats fed with E. arborea became more anti-allergic, suggesting that E. arborea might possess anti-allergic effects.
- Subjects
BROWN algae; LOW-allergen plants; RATTUS norvegicus; LABORATORY rats; IMMUNOGLOBULIN E; HISTAMINE; CYTOKINES; INTERFERONS; INTERLEUKIN-4; EISENIA (Algae)
- Publication
Fisheries Science, 2008, Vol 74, Issue 1, p180
- ISSN
0919-9268
- Publication type
Article
- DOI
10.1111/j.1444-2906.2007.01508.x