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- Title
Dihydroavenanthramide D prevents UV-irradiated generation of reactive oxygen species and expression of matrix metalloproteinase-1 and -3 in human dermal fibroblasts.
- Authors
Kim, Jeong ‐ Mi; Noh, Eun ‐ Mi; Kwon, Kang ‐ Beom; Hwang, Bo ‐ Mi; Hwang, Jin ‐ Ki; You, Yong ‐ Ouk; Kim, Min Seuk; Lee, Wan; Lee, Jeong ‐ Ho; Kim, Hye ‐ Jung; Kim, Jong ‐ Suk; Lee, Young ‐ Rae
- Abstract
Ultraviolet B ( UVB) radiation induces photoageing by upregulating the expression of matrix metalloproteinases ( MMPs) in human skin cells. Dihydroavenanthramide D ( DHAvD) is a synthetic analog to naturally occurring avenanthramide, which is the active component in oats. Although anti-inflammatory, anti-atherosclerotic and antioxidant effects have been reported, the antiphotoageing effects of DHAv D are yet to be understood. In this study, we investigated the inhibitory effects of DHAv D on UVB-induced production of reactive oxygen species ( ROS) and expression of MMPs, and its molecular mechanism in UVB-irradiated human dermal fibroblasts. Western blot and real-time PCR analyses revealed that DHAv D inhibited UVB-induced MMP-1 and MMP-3 expression. It also significantly blocked UVB-induced ROS generation in fibroblasts. Additionally, DHAv D attenuated UVB-induced phosphorylation of MAPKs, activation of NF-κB and AP-1. DHAv D regulates UVB-irradiated MMP expression by inhibiting ROS-mediated MAPK/ NF-κB and AP-1 activation. DHAv D may be a useful candidate for preventing UV light-induced skin photoageing.
- Subjects
ULTRAVIOLET radiation; PATHOLOGICAL physiology; MATRIX metalloproteinases; FIBROBLASTS; MITOGEN-activated protein kinases; SKIN diseases
- Publication
Experimental Dermatology, 2013, Vol 22, Issue 11, p759
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/exd.12243