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- Title
Monitoring neuropeptide-specific proteases: processing of the proopiomelanocortin peptides adrenocorticotropin and α-melanocyte-stimulating hormone in the skin.
- Authors
König, Simone; Luger, Thomas A.; Scholzen, Thomas E.
- Abstract
The neuroendocrine precursor protein proopiomelanocortin (POMC) and its derived neuropeptides are involved in a number of important regulatory processes in the central nervous system as well as in peripheral tissues. Despite its important role in controlling the local activation of melanocortin (MC) receptors, the extracellular proteolytic processing of POMC peptides has received little attention. The mechanisms relevant for controlling the bioavailability of adrenocorticotropin and melanocyte-stimulating hormones for the corresponding MC receptors in the skin by specific peptidases such as neprilysin (neutral endopeptidase; NEP) or angiotensin-converting enzyme (ACE) have been addressed in a number of recent investigations. This review summarizes the current body of knowledge concerning the qualitative and quantitative POMC peptide processing with respect to the action and specificity of NEP and ACE and discusses relevant recent analytical methodologies.
- Subjects
PROOPIOMELANOCORTIN; NEUROPEPTIDES; CENTRAL nervous system; ADRENOCORTICOTROPIC hormone; IMMUNOSPECIFICITY
- Publication
Experimental Dermatology, 2006, Vol 15, Issue 10, p751
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/j.1600-0625.2006.00472.x