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- Title
Dietary influences on 8-MOP plasma levels in PUVA patients with psoriasis.
- Authors
Roelandts, R.; Van Boven, M.; Deheyn, T.; Vander Stichele, G.; Degreef, H.; Daenens, P.
- Abstract
To Study the effect of diet on 8-MOP plasma levels, these levels were measured three times in twenty PUVA patients with psoriasis; while fasting, after a low-fat breakfast, and after a fat-rich breakfast. No significant differences were found between the maximal 8-MOP plasma levels in the fasting condition and the levels after the low-fat breakfast, both peaking 2 h after ingestion. After the fat-rich breakfast, however, the 8-MOP plasma levels were not only significantly lower at 2 h but also peaked later, reaching their maximum at 3–4 h after intake. The drug should therefore be given in a dietetically standardized way. This raises the question whether some cases of therapy resistance can be dietetically influenced.
- Subjects
PSORIASIS; SKIN diseases; DIET; BLOOD plasma; DRUGS; THERAPEUTICS
- Publication
British Journal of Dermatology, 1981, Vol 105, Issue 5, p569
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1981.tb00801.x