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- Title
Anti-inflammatory Agents in the Treatment of Diabetes and Its Vascular Complications.
- Authors
Pollack, Rena M.; Donath, Marc Y.; LeRoith, Derek; Leibowitz, Gil
- Abstract
The association between hyperglycemia and inflammation and vascular complications in diabetes is now well established. Antidiabetes drugs may alleviate inflammation by reducing hyperglycemia; however, the anti-inflammatory effects of these medications are inconsistent and it is unknown whether their beneficial metabolic effects are mediated via modulation of chronic inflammation. Recent data suggest that immunomodulatory treatments may have beneficial effects on glycemia, β-cell function, and insulin resistance. However, the mechanisms underlying their beneficial metabolic effects are not always clear, and there are concerns regarding the specificity, safety, and efficacy of immune-based therapies. Herein, we review the anti-inflammatory and metabolic effects of current antidiabetes drugs and of anti-inflammatory therapies that were studied in patients with type 2 diabetes. We discuss the potential benefit of using anti-inflammatory treatments in diabetes and important issues that should be addressed prior to implementation of such therapeutic approaches.
- Subjects
ANTI-inflammatory agents; TREATMENT of diabetes; HYPERGLYCEMIA; INFLAMMATION; MEDICATION safety; DRUG efficacy; PEOPLE with diabetes; DISEASE risk factors; BLOOD sugar; CARDIOVASCULAR diseases; DIABETIC angiopathies; INSULIN resistance; TYPE 2 diabetes; DISEASE complications
- Publication
Diabetes Care, 2016, Vol 39, pS244
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dcS15-3015