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- Title
β-eudesmol suppresses allergic reactions via inhibiting mast cell degranulation.
- Authors
Han, Na‐Ra; Moon, Phil‐Dong; Ryu, Ka‐Jung; Jang, Jae‐Bum; Kim, Hyung‐Min; Jeong, Hyun‐Ja
- Abstract
The regulatory effect of β-eudesmol, which is an active constituent of Pyeongwee-San ( KMP6), is evaluated for allergic reactions induced by mast cell degranulation. Phorbol 12-myristate 13-acetate ( PMA) plus calcium ionophore A23187-stimulated human mast cell line, HMC-1 cells, and compound 48/80-stimulated rat peritoneal mast cells ( RPMCs) are used as the in vitro models; mice models of systemic anaphylaxis, ear swelling, and IgE-dependent passive cutaneous anaphylaxis ( PCA) are used as the in vivo allergic models. The results demonstrate that β-eudesmol suppressed the histamine and tryptase releases from the PMA plus calcium ionophore A23187-stimulated HMC-1 cells. β-eudesmol inhibits the expression and activity of histidine decarboxylase in the activated HMC-1 cells. In addition, β-eudesmol inhibits the levels of histamine and tryptase released from the compound 48/80-stimulated RPMCs. Furthermore, β-eudesmol decreases the intracellular calcium level in the activated RPMCs. β-eudesmol also decreases the compound 48/80-induced mortality and ear swelling response. β-eudesmol suppresses the serum levels of histamine, IgE, interleukin ( IL)-1β, IL-4, IL-5, IL-6, IL-13, and vascular endothelial growth factor ( VEGF) under PCA mice as well as PCA reactions. Therefore, the results from this study indicate the potential of β-eudesmol as an anti-allergic drug with respect to its pharmacological properties against mast cell-mediated allergic reactions.
- Subjects
ANAPHYLAXIS; ALLERGY treatment; ANTIALLERGIC agents; OTITIS externa; HISTAMINE; MAST cells; THERAPEUTICS
- Publication
Clinical & Experimental Pharmacology & Physiology, 2017, Vol 44, Issue 2, p257
- ISSN
0305-1870
- Publication type
Article
- DOI
10.1111/1440-1681.12698