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- Title
The role of the spleen in malaria.
- Authors
del Portillo, Hernando A.; Ferrer, Mireia; Brugat, Thibaut; Martin-Jaular, Lorena; Langhorne, Jean; Lacerda, Marcus V. G.
- Abstract
Summary The spleen is a complex organ that is perfectly adapted to selectively filtering and destroying senescent red blood cells (RBCs), infectious microorganisms and Plasmodium-parasitized RBCs. Infection by malaria is the most common cause of spleen rupture and splenomegaly, albeit variably, a landmark of malaria infection. Here, the role of the spleen in malaria is reviewed with special emphasis in lessons learned from human infections and mouse models.
- Subjects
SPLEEN diseases; MALARIA; ERYTHROCYTES; MICROORGANISMS; PLASMODIUM; PARASITIC diseases; LABORATORY mice
- Publication
Cellular Microbiology, 2012, Vol 14, Issue 3, p343
- ISSN
1462-5814
- Publication type
Article
- DOI
10.1111/j.1462-5822.2011.01741.x