We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Women With Gestational Diabetes Mellitus Randomized to a Higher-Complex Carbohydrate/Low-Fat Diet Manifest Lower Adipose Tissue Insulin Resistance, Inflammation, Glucose, and Free Fatty Acids: A Pilot Study.
- Authors
Hernandez, Teri L.; Van Pelt, Rachael E.; Anderson, Molly A.; Reece, Melanie S.; Reynolds, Regina M.; de la Houssaye, Becky A.; Heerwagen, Margaret; Donahoo, William T.; Daniels, Linda J.; Chartier-Logan, Catherine; Janssen, Rachel C.; Friedman, Jacob E.; Barbour, Linda A.
- Abstract
<bold>Objective: </bold>Diet therapy in gestational diabetes mellitus (GDM) has focused on carbohydrate restriction but is poorly substantiated. In this pilot randomized clinical trial, we challenged the conventional low-carbohydrate/higher-fat (LC/CONV) diet, hypothesizing that a higher-complex carbohydrate/lower-fat (CHOICE) diet would improve maternal insulin resistance (IR), adipose tissue (AT) lipolysis, and infant adiposity.<bold>Research Design and Methods: </bold>At 31 weeks, 12 diet-controlled overweight/obese women with GDM were randomized to an isocaloric LC/CONV (40% carbohydrate/45% fat/15% protein; n = 6) or CHOICE (60%/25%/15%; n = 6) diet. All meals were provided. AT was biopsied at 37 weeks.<bold>Results: </bold>After ∼7 weeks, fasting glucose (P = 0.03) and free fatty acids (P = 0.06) decreased on CHOICE, whereas fasting glucose increased on LC/CONV (P = 0.03). Insulin suppression of AT lipolysis was improved on CHOICE versus LC/CONV (56 vs. 31%, P = 0.005), consistent with improved IR. AT expression of multiple proinflammatory genes was lower on CHOICE (P < 0.01). Infant adiposity trended lower with CHOICE (10.1 ± 1.4 vs. 12.6 ± 2%, respectively).<bold>Conclusions: </bold>A CHOICE diet may improve maternal IR and infant adiposity, challenging recommendations for a LC/CONV diet.
- Subjects
GESTATIONAL diabetes; COMPLEX carbohydrate diet; LOW-fat diet; ADIPOSE tissues; INSULIN resistance; INFLAMMATION; FREE fatty acids; GLUCOSE; REDUCING diets; BLOOD sugar; COMPARATIVE studies; FASTING; FATTY acids; GLYCEMIC index; INSULIN; RESEARCH methodology; MEDICAL cooperation; OBESITY; RESEARCH; RESEARCH funding; PILOT projects; EVALUATION research; RANDOMIZED controlled trials
- Publication
Diabetes Care, 2016, Vol 39, Issue 1, p39
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc15-0515