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- Title
Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci.
- Authors
Chen, Mingliang; Harrison, Odile B.; Bratcher, Holly B.; Zhiyan Bo; Jolley, Keith A.; Rodrigues, Charlene M. C.; Bray, James E.; Qinglan Guo; Xi Zhang; Min Chen; Maiden, Martin C. J.; Bo, Zhiyan; Guo, Qinglan; Zhang, Xi; Chen, Min
- Abstract
Expansion of quinolone-resistant Neisseria meningitidis clone ChinaCC4821-R1-C/B from sequence type (ST) 4821 clonal complex (CC4821) caused a serogroup shift from serogroup A to serogroup C invasive meningococcal disease (IMD) in China. To determine the relationship among globally distributed CC4821 meningococci, we analyzed whole-genome sequence data from 173 CC4821 meningococci isolated from 4 continents during 1972-2019. These meningococci clustered into 4 sublineages (1-4); sublineage 1 primarily comprised of IMD isolates (41/50, 82%). Most isolates from outside China (40/49, 81.6%) formed a distinct sublineage, the Europe-USA cluster, with the typical strain designation B:P1.17-6,23:F3-36:ST-3200(CC4821), harboring mutations in penicillin-binding protein 2. These data show that the quinolone-resistant clone ChinaCC4821-R1-C/B has expanded to other countries. The increasing distribution worldwide of serogroup B CC4821 raises the concern that CC4821 has the potential to cause a pandemic that would be challenging to control, despite indirect evidence that the Trumenba vaccine might afford some protection.
- Subjects
CHINA; EUROPE; PENICILLIN-binding proteins; MENINGOCOCCAL infections; NEISSERIA; NEISSERIA meningitidis; PANDEMICS; RESEARCH; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; MENINGOCOCCAL vaccines; SEROTYPES; COMPARATIVE studies; GRAM-negative aerobic bacteria; QUINOLONE antibacterial agents
- Publication
Emerging Infectious Diseases, 2021, Vol 27, Issue 4, p1110
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2704.203612