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- Title
Fluoroquinolone-resistant Escherichia coli, Indonesia.
- Authors
Kuntaman, Kuntaman; Sri Lestari, Endang; Severin, Juliëtte A.; Kershof, Irma M.; Mertaniasih, Ni Made; Purwanta, Marijam; Hadi, Usman; Johnson, James R.; Van Belkum, Alex; Verbrugh, Henri A.; Lestari, Endang Sri; Severin, Juliëtte A; Antimicrobial Resistance in Indonesia, Prevalence and Prevention Study Group
- Abstract
In a recent, population-based survey of 3,996 persons in Indonesia, fluoroquinolone (FQ)-resistant Escherichia coli was prevalent in the fecal flora of 6% of patients at hospital admission and 23% of patients at discharge, but not among healthy relatives or patients visiting primary healthcare centers (2%). Molecular typing showed extensive genetic diversity with only limited clonality among isolates. This finding suggests that independent selection of resistant mutants occurs frequently. FQ-resistant isolates exhibited a higher rate of spontaneous mutation, but sparser virulence profiles, than FQ-susceptible isolates from the same population. The resistant isolates belonged predominantly to phylogenetic groups A (57%) and B1 (22%) but also to the moderately virulent group D (20%). Hypervirulent strains from the B2 cluster were underrepresented (1%). Because FQ-resistant E. coli can cause disease, especially nosocomial infections in immunocompromised patients, spread of such strains must be stopped.
- Subjects
INDONESIA; ESCHERICHIA coli; ESCHERICHIA; BOTANY; FECES; ANTI-infective agents; COMPARATIVE studies; DRUG resistance in microorganisms; BIOLOGICAL evolution; GENETICS; RESEARCH methodology; MEDICAL cooperation; MICROBIAL sensitivity tests; MOLECULAR biology; QUINOLONE antibacterial agents; RESEARCH; EVALUATION research; PHARMACODYNAMICS
- Publication
Emerging Infectious Diseases, 2005, Vol 11, Issue 9, p1363
- ISSN
1080-6040
- Publication type
journal article