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- Title
Cryptococcus neoformans Infection in Organ Transplant Recipients: Variables Influencing Clinical Characteristics and Outcome.
- Authors
Husain, Shahid; Wagener, Marilyn M.; Singh, Nina
- Abstract
Unique clinical characteristics and other variables influencing the outcome of Cryptococcus neoformans infection in organ transplant recipients have not been well defined. From a review of published reports, we found that C. neoformans infection was documented in 2.8% of organ transplant recipients (overall death rate 42%). The type of primary immunosuppressive agent used in transplantation influenced the predominant clinical manifestation of cryptococcosis. Patients receiving tacrolimus were significantly less likely to have central nervous system involvement (78% versus 11%, p = 0.001) and more likely to have skin, soft-tissue, and osteoarticular involvement (66% versus 21%, p = 0.006) than patients receiving nontacrolimus-based immunosuppression. Renal failure at admission was the only independently significant predictor of death in these patients (odds ratio 16.4, 95% CI 1.9-143, p = 0.004). Hypotheses based on these data may elucidate the pathogenesis and may ultimately guide the management of C. neoformans infection in organ transplant recipients.
- Subjects
CRYPTOCOCCUS neoformans; COMPLICATIONS from organ transplantation; TRANSPLANTATION immunology; MYCOSES
- Publication
Emerging Infectious Diseases, 2001, Vol 7, Issue 3, p375
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid0703.010302