We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparison of cardiac Z-score with cardiac asymmetry for prenatal screening of congenital heart disease.
- Authors
Riggs, T.; Saini, A. P.; Comstock, C. H.; Lee, W.
- Abstract
Objective To determine the best screening tests for discriminating early indicators of cardiac hypoplasia in congenital heart disease (CHD) from normal variations in fetal cardiac growth. Methods We retrospectively examined fetal echocardiograms from 90 infants with confirmed CHD: Group 1 ( n = 35) with right-sided obstructive lesions and Group 2 ( n = 55) with left-sided obstructive lesions. Our control group comprised 2735 normal fetuses, from which we determined fetal cardiac Z-scores of right ventricle (RV), left ventricle (LV), aorta (Ao) and pulmonary artery (PA) diameters and ratios of right to left ventricle (RV:LV) and pulmonary artery to aorta (PA:Ao) size. We compared our control group to Groups 1 and 2 using ANOVA and area under receiver-operating characteristics curve (AUC) analysis. Results For Group 1, RV:LV ratio, RV-Z-score and PA:Ao ratio were the best screening tests, with highest AUCs (0.879, 0.868 and 0.832, respectively). For Group 2, the Ao-Z-score, PA:Ao and RV:LV ratios were the best screening tests, with AUCs of 0.770, 0.723 and 0.716, respectively. Conclusion None of the screening tests was found to be a perfect early discriminator for the cardiac lesions tested. Although ratios of PA:Ao and RV:LV are useful, they should be combined with fetal cardiac Z-scores to maximize screening sensitivity. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
- Subjects
CONGENITAL heart disease diagnosis; FETAL echocardiography; ANALYSIS of variance; RIGHT heart ventricle; LEFT heart ventricle; PULMONARY artery
- Publication
Ultrasound in Obstetrics & Gynecology, 2011, Vol 38, Issue 3, p332
- ISSN
0960-7692
- Publication type
Article
- DOI
10.1002/uog.8989