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- Title
Antiviral Activity of Folium Isatidis Derived Extracts In Vitro and In Vivo.
- Authors
You-Ping Deng; Yuan-Yuan Liu; Zhao Liu; Jin Li; Ling-Min Zhao; Hong Xiao; Xiao-Hua Ding; Zhan-Qiu Yang
- Abstract
Folium isatidis is a native Chinese herbaceous plant widely used for medicinal purposes for thousands of years. However, few studies have focused on the leaves of Isatis indigotica. In this report, we isolated a series of four fractions (I-IV) from Folium isatidis and explored the antiviral activity of each tested extract. The extracts were active against a panel of RNA and DNA viruses in vitro, namely influenza A virus (1AV), coxsackie virus B3 (CVB3), respiratory syncytial virus (RSV), and adenovirus type 7 (Ad-7). Oral administration of 200 mg/kg/d of fraction III in mice exerted strong antiviral effects in viral replication, accompanied by prolonged survival rate, attenuated lung tissue damage as well as significant reductions in pulmonary virus titers and lung index. Our results provide the first biochemical evidence that Folium isatidis and its extracts could be used as potential antiviral agent in the postexposure prophylaxis for multiple viral infections.
- Subjects
PHYTOTHERAPY; VIRUS disease drug therapy; ANIMAL experimentation; BIOPHYSICS; RESEARCH methodology; MICE; PROBABILITY theory; RESEARCH funding; STATISTICS; DATA analysis; DATA analysis software; DESCRIPTIVE statistics; KAPLAN-Meier estimator; IN vitro studies; LOG-rank test
- Publication
American Journal of Chinese Medicine, 2013, Vol 41, Issue 4, p957
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/S0192415X1350064X