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- Title
Indicators for cognitive performance and subjective cognitive complaints in multiple sclerosis: a role for advanced MRI?
- Authors
Hulst, Hanneke E; Gehring, Karin; Uitdehaag, Bernard MJ; Visser, Leo H; Polman, Chris H; Barkhof, Frederik; Sitskoorn, Margriet M; Geurts, Jeroen JG
- Abstract
Previous studies showed that advanced neuroimaging measures (functional MRI, diffusion tensor imaging) could distinguish multiple sclerosis (MS) patients with and without cognitive impairment. Are these measures indeed better indicators for cognitive impairment or subjective cognitive complaints than conventional MRI?Fifty MS patients and 29 controls were investigated. Regression analysis, including socio-demographic data, disease characteristics, psychological measures, and (advanced) neuroimaging, showed that worse cognitive performance was associated with male sex, lower education, and lower gray matter volume. Subjective cognitive complaints were associated with fatigue and less hippocampal atrophy. Advanced MRI measures did not add to the predictive power of our model.
- Subjects
MULTIPLE sclerosis; DEMYELINATION; MYELIN sheath diseases; COGNITION; MEDICAL imaging systems
- Publication
Multiple Sclerosis Journal, 2014, Vol 20, Issue 8, p1131
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458513513969