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- Title
Formulation, Development and Characterization of Ethosomal Gel of Atorvastatin.
- Authors
Agrawal, Shivendra; Gautam, Girendra Kumar
- Abstract
The current study was conducted to develop vesicular ethosomal gel system for antihypertensive drug atorvastatin. Atorvastatin, aHMG-CoA reductase inhibitor used in the treatment of congestive heart failure (CHF). Atorvastatin was formulated in to ethosomal gel formulation to reduce the first pass metabolism and increase the systemic bioavailability. Ethosomes composed of phospholipids oya lecithin, ethanol and cholesterol were prepared by cold method followed by ultrasonicat ion. The atorvastatin ethosomes were then characterized for their particle size, zeta potential followed by invitro drug release profile. The optimized ethosoml formulation was then incorporated in to gellinga gent, carbopol 934 to prepare ethosomal gel formulation. The ethosomal gel formulat ion was then subjected to physicochemical characterization, spreadibility and invitro drug release profile. The ethosomal gel formulation showed 15.69g. cm spreadibility and 98.13% invitro drug release with in 48 hours as compared to plan drug ethosomal formulation which shows 52.37 % in 48 hours. Hence ethosomal gel delivery system provide a good design for topical delivery of drug with enhanced bioavailability and patient compliance.
- Subjects
DRUG solubility; LECITHIN; ATORVASTATIN; CONGESTIVE heart failure; COLLOIDS; DRUG bioavailability; REDUCTASE inhibitors
- Publication
International Journal of Pharmacy & Life Sciences, 2020, Vol 11, Issue 7, p70
- ISSN
0976-7126
- Publication type
Article