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- Title
Evaluation of antidiabetic and antihyperlipidemic activity of Abelmoschus esculentus (L.) in diabetic rats.
- Authors
Singh, Ranjeet; Choudhary, Fatma; Chahal, Piyush
- Abstract
The present investigation was aimed to study the antidiabetic and antihyperlipidemic potential of Abelmoschus esculentus Leaf extract (AELE) in streptozotocin (STZ)-induced diabetic rats. Acute toxicity of AELP was studied in rats at 2000 mg/kg dose and diabetes was induced in rats by administration of STZ (60 mg/kg, i.p.). After 14 days of blood glucose stabilization, diabetic rats received AELE, and glibenclamide up to 28 days. The blood samples were collected on day 28 to estimate the biochemical parameter and lipid profile estimation in EDTA blood vial. In acute toxicity study, AELE did not show any toxicity or death up to a dose of 2000 mg/kg. Therefore, to assess the antidiabetic action, Administration of AELE at one by tenth and one by fifth dose of AELE in diabetic rats showed significant (P < 0.001) reduction in blood glucose level and increase in body weight than diabetic control rats. A significant (P < 0.001) increased level of Hb, TP, and decreased level of SGPT were observed after the treatment. Also, elevated lipid profile levels returned to near normal in diabetic rats after the administration of AELE compared to diabetic control rats.
- Subjects
GLYCEMIC control; RATS; BLOOD sugar; OKRA; RAT control; BODY weight
- Publication
International Journal of Pharmacy & Life Sciences, 2019, Vol 10, Issue 6, p87
- ISSN
0976-7126
- Publication type
Article