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- Title
EVALUATION OF HEPATOPROTECTIVE POTENTIAL OF PTEROSPERMUM ACERIFOLIUM IN DRUG INDUCED OXIDATIVE STRESS.
- Authors
Varandani, Deepa; Jain, Sourabh; Dubey, Raghvendra
- Abstract
The hydroalcoholic extract of Pterospermum acerifolium were investigated for antioxidant and hepatoprotective potential for drug induced hepatotoxicity and oxidative stress condition. The stable 1, 1-diphenyl-2-picryl hydrazyl radical (DPPH) was used for determination of free radical-scavenging activity and the effect on enzymes involved in oxidative stress were analyzed by SOD, GSH, LPO and Catalase. The experiment were performed on toxicity induced liver. The liver was homogenized into ice cold acid buffer and the supernatant was used for evaluation. It was observed that extract showed good line of fit for % inhibition in concentration range of 10-50mcg/ml with R²=0.99. The level of SOD, GSH and CAT was significantly less (P<0.05) as compared to vehicle treated group which was sign of oxidative stress in liver due to drug induced toxic metabolites. The LPO level was also found to significantly high (P<0.05) as compared to vehicle treated group. The results of present study showed that Pterospermum acerifoliumextract possess significant hepatoprotective potential.
- Subjects
OXIDATIVE stress; HEPATOTOXICOLOGY; DRUGS; CATALASE
- Publication
International Journal of Pharmacy & Life Sciences, 2019, Vol 10, Issue 6, p59
- ISSN
0976-7126
- Publication type
Article