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- Title
ELOQUENT WOUND HEALING ACTIVITY BY GALINSOGA PARVIFLORA LEAVES EXTRACT.
- Authors
Tagde, Priti; Sharma, Shailja
- Abstract
Wound healing is achieved through four coordinated and protruding episodes. In under damaged skin, epidermis and dermis form a protective barrier against external environment. When barrier is broken, a regulated sequence of biochemical events is set into motion to repair the damage. This process is divided into predictable phases likewise Haemostasis, Inflammatory, Proliferative and Remodelling. The complex process can be disrupted by local or systemic risk factors, resulting in delayed healing and progression to chronic wound. The physician plays a significant role in handling such situations. Strategies for effective wound healing include optimising local wound care. Ethanolic extract of leaves of Galensoga parviflora were evaluated for wound healing activity. The ethanolic extract of 10% w/w ointment exhibit equivalent wound healing activity as povidine iodide. Extract in the form of ointment is applied topically on excision; incision models in mice showed marked healing process as evidenced by increased rate of wound closure time. Histological analysis of tissue after 14-21 days from extract treated group showed increased, well organised bands of collagen, macrophage, fibroblast, blood vessels compared to control, which expresses eloquent wound healing activity by Galinsoga parviflora leaves extract.
- Subjects
WOUND healing; GRANULATION tissue; WOUND care; CHRONIC wounds &; injuries; EXTRACTS; LEAVES; TISSUE analysis
- Publication
International Journal of Pharmacy & Life Sciences, 2019, Vol 10, Issue 6, p43
- ISSN
0976-7126
- Publication type
Article