We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mechanobiology of Ciliogenesis.
- Authors
Ishikawa, Hiroaki; Marshall, Wallace F.
- Abstract
Cilia are force-generating and -sensing organelles that serve as mechanical interfaces between the cell and the extracellular environment. Cilia are present in tissues that adaptively respond to mechanical loading and fluid flow, and defects in ciliary function can lead to diseases affecting these tissues. As might be expected for a mechanical interface, the formation of cilia is, itself, regulated by mechanical forces, and these links between mechanics and ciliary formation are providing new entry points for dissecting the regulatory pathways of ciliogenesis.
- Subjects
CILIA &; ciliary motion; CELLULAR mechanics; DEVELOPMENTAL biology; HYDRODYNAMICS; CELLULAR control mechanisms; REGULATION of cell growth; ORGANELLE development; BIOMECHANICS
- Publication
BioScience, 2014, Vol 64, Issue 12, p1084
- ISSN
0006-3568
- Publication type
Article
- DOI
10.1093/biosci/biu173