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- Title
Fecal short chain fatty acids modify therapeutic effects of sleeve gastrectomy.
- Authors
Chongrong Shen; Yanru Chen; Qiaoling Wang; Yingkai Sun; Huibin Lin; Mengshan Ni; Yufei Chen; Ling Zhang; Jiabin Jin; Xiayang Ying; Yuyao Zou; Xiaolin Wang; Yaorui Ye; Miaomiao Yuan; Nan Yin; Zhiwen Cao; Yifei Zhang; Weiqiong Gu; Weiqing Wang; Guang Ning
- Abstract
Aims: We aimed to investigate changes of fecal short chain fatty acids (SCFAs) and their association with metabolic benefits after sleeve gastrectomy (SG). Specifically, whether pre-surgery SCFAs modify surgical therapeutic effects was determined. Methods: 62 participants with measurements of fecal SCFAs and metabolic indices before and 1, 3, 6 months after SG were included. Changes of fecal SCFAs and their association with post-surgery metabolic benefits were calculated. Then, participants were stratified by medians of pre-surgery fecal SCFAs and modification effects of pre-surgery fecal SCFAs on surgical therapeutic effects were investigated, through calculating interaction of group by surgery. Results: Fecal SCFAs were markedly changed by SG. Changes of propionate and acetate were positively correlated with serum triglycerides and total cholesterol, respectively. Notably, high pre-surgery fecal hexanoate group showed a better effect of SG treatment on lowering body weight (P=0.01), BMI (P=0.041) and serum triglycerides (P=0.031), and low pre-surgery fecal butyrate had a better effect of SG on lowering ALT (P=0.003) and AST (P=0.019). Conclusion: Fecal SCFAs were changed and correlated with lipid profiles improvement after SG. Pre-surgery fecal hexanoate and butyrate were potential modifiers impacting metabolic benefits of SG.
- Subjects
SHORT-chain fatty acids; SLEEVE gastrectomy; BUTYRATES; BODY weight
- Publication
Frontiers in Endocrinology, 2023, p1
- ISSN
1664-2392
- Publication type
Article
- DOI
10.3389/fendo.2023.1277035