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- Title
Catalytic Enantioconvergent C(sp<sup>3</sup>)−N Coupling to Access Chiral Amines: A Concept Review.
- Authors
Li, Rongrong; Hu, Zhiyun; Shuai, Zhigang; Yang, Xinzheng
- Abstract
Nitrogen containing compounds like chiral amines have been widely used in synthetic medicines, biomass, and fine chemical products because of their particularly valuable motifs and exceedingly broad range of functionality. Enantioconvergent synthesis of chiral amines has high atomic economy and enantioselectivity with theoretically 100 % yield of enantioenriched products. In this concept article, we hope to provide a further understanding of chiral amines enantioconvergent synthesis methodology with an introduction of recent progresses in enantioconvergent amination reactions catalyzed by early transition metals and facilitate the development of enantioconvergent C(sp3)−N coupling for benign and efficient preparation of highly valuable chiral nitrogen‐containing units.
- Subjects
TRANSITION metal catalysts; AMINATION; TRANSITION metals; AMINES; BIOMASS
- Publication
ChemCatChem, 2024, Vol 16, Issue 15, p1
- ISSN
1867-3880
- Publication type
Article
- DOI
10.1002/cctc.202400049