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- Title
Variation in hemolytic activity of Brachyspira hyodysenteriae strains from pigs.
- Authors
Mahu, Maxime; De Pauw, Nele; Maele, Lien Vande; Verlinden, Marc; Boyen, Filip; Ducatelle, Richard; Haesebrouck, Freddy; Martel, An; Pasmans, Frank
- Abstract
Brachyspira hyodysenteriae is the primary cause of swine dysentery, which is responsible for major economic losses to the pig industry worldwide. The hemolytic activity of 10 B. hyodysenteriae strains isolated from stools of pigs with mild to mucohemorrhagic diarrhea was compared and seven hemolysis associated genes were sequenced. Hemolysis induced by these strains varied from strong to near absent. One weakly hemolytic B. hyodysenteriae strain showed sequence changes in five hemolysis associated genes (tlyA, tlyB, hemolysin III, hemolysin activation protein and hemolysin III channel protein) resulting in amino acid substitutions. The occurrence of weakly hemolytic strains identifiable as B. hyodysenteriae should be taken into account in swine dysentery diagnostics. The presence of these strains may affect herd dysentery status, with great impact on a farms trading opportunities.
- Subjects
TREPONEMA hyodysenteriae; SWINE dysentery; SWINE industry; HEMOLYSIS &; hemolysins; SWINE diseases
- Publication
Veterinary Research, 2016, Vol 47, p1
- ISSN
0928-4249
- Publication type
Article
- DOI
10.1186/s13567-016-0353-x