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- Title
Fluoroquinolone-Induced Photosensitivity: A Chemical Fragment-Based Approach by a Case/Non-case Study in VigiBase<sup>®</sup>.
- Authors
Zelmat, Yoann; Rousseau, Vanessa; Chebane, Leila; Montastruc, Jean-Louis; Bagheri, Haleh; Sommet, Agnès
- Abstract
<bold>Introduction: </bold>Fluoroquinolones are widely used to treat bacterial infections. Many in vitro and in vivo studies have established a chemical relationship between fluoroquinolones' particular chemical structure and photosensitivity. The aim of this study was to establish a relationship between the chemical structure of fluoroquinolones and the risk of photosensitivity adverse effects from real-world data.<bold>Methods: </bold>All the Individual Case Safety Reports (ICSRs) related to fluoroquinolones and registered in the World Health Organization global database (VigiBase®) up to December 31, 2017 were collected. A disproportionality analysis was performed in order to quantify the photosensitivity risk for each fluoroquinolone by calculating their reporting odds ratio (ROR).<bold>Results: </bold>Up to December 31, 2017, 282,805 ICSRs related to fluoroquinolones were selected, of which 1647 were photosensitivity adverse event cases. Sparfloxacin had the highest adjusted ROR of 161.10 (95% confidence interval [CI] 133.66-194.02) followed by grepafloxacin (40.30 [26.30-59.60]) closely followed by lomefloxacin (32.61 [28.61-37.07]), then enoxacin (11.04 [8.33-14.32]) and fleroxacin (8.22 [5.06-12.56]).<bold>Conclusion: </bold>This study confirms the high reporting rate of photosensitivity adverse effects for sparfloxacin from real-world data. Moreover, our data suggest more photosensitivity adverse effects reporting for fluoroquinolones with a halogen at their 8th position.
- Subjects
FLUOROQUINOLONES; PHOTOSENSITIVITY; HALOGEN compounds; CHEMICAL structure; ADVERSE health care events
- Publication
Drug Safety, 2020, Vol 43, Issue 6, p561
- ISSN
0114-5916
- Publication type
journal article
- DOI
10.1007/s40264-020-00917-4