We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2.
- Authors
Lian Dee Ler; Ghosh, Sujoy; Xiaoran Chai; Aye Aye Thike; Hong Lee Heng; Ee Yan Siew; Dey, Sucharita; Liang Kai Koh; Jing Quan Lim; Weng Khong Lim; Swe Swe Myint; Jia Liang Loh; Pauline Ong; Xin Xiu Sam; Dachuan Huang; Lim, Tony; Puay Hoon Tan; Nagarajan, Sanjanaa; Sam Cheng, Christopher Wai; Ho, Henry
- Abstract
The article presents a study that demonstrate that tumor suppressor KDM6A is frequently lost in both muscle-invasive and non-muscle-invasive urothelial bladder carcinoma, resulting in enrichment in Polycomb-repressive complex 2 (PRC2)-regulated signaling, which is antagonistic to the trl complex-regulated signaling. Topics discussed include establishment of the therapeutic potential of EZH2 inhibition in KDM6A-null or PRC2-enriched urothelial bladder carcinoma.
- Subjects
TUMOR suppressor genes; TUMOR suppressor proteins; TRANSITIONAL cell carcinoma; POLYCOMB group proteins; PROTEINS
- Publication
Science Translational Medicine, 2017, Vol 9, Issue 378, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aai8312