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- Title
SPECTRUM OF METABOLIC BONE DISEASE- A CASE SERIES.
- Authors
Sinha, Rahul; Sharma, Vinod; Sharma, Raghav; Pandey, Kavita
- Abstract
Bone is a complex organ that is metabolically active, particularly in children. Normal metabolism is dependent upon the three main elements: matrix, mineral and cells that are integral components of bone. In addition there are several hormonal factors that also influence bone metabolism. Abnormalities in any of these components can give rise to metabolic bone disease. The manifestations of deficiency may vary from hypocalcemic seizures, tetany in infancy and adolescence to florid rickets in toddlers. Treatment is necessary for all individuals with deficiency whether symptomatic or not and consists of vitamin D supplementation as Stoss therapy or daily or weekly oral regimens with equal efficacy and safety, combined with calcium supplements. In this article we present three different cases of metabolic bone disease with varied features which the clinician should keep in mind while dealing with these cases. This case series adds a wide spectrum to the diagnosis and management of metabolic bone disease.
- Subjects
RICKETS; BONE injuries; VITAMIN D; CALCIUM; BONE metabolism; DIAGNOSIS
- Publication
Pediatric Oncall Journal, 2017, Vol 14, Issue 2, p35
- ISSN
0973-0966
- Publication type
Article
- DOI
10.7199/ped.oncall.2017.47