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- Title
Evolution of HER2 Testing in Canada.
- Authors
Hanna, Wedad M.
- Abstract
Purpose: The accuracy of HER2 testing plays a critical role in identifying patients who may benefit from HER2-directed therapy. Canadian Consensus for HER2/neu Testing Guidelines in Breast Cancer was published in 2007 with the aim of improving the accuracy of HER2 testing across Canada. Method: The authors surveyed Canadian pathologists with responsibility for HER2 testing of breast cancer samples to assess the impact of the Canadian consensus guidelines on current HER2 testing procedures. Thirty-six expert pathologists were invited to participate in an online survey between April 19 and May 28, 2010. Results: Responses were received from 22 pathologists (61%). All but one of the respondents performed HER2 testing in accordance with American Society of Clinical Oncology/CAP/Canadian consensus guidelines and used the same HER2 testing algorithm in the adjuvant and metastatic settings. All respondents participated in a quality assurance program, and concordance between HER2 testing results at local and central testing centres was high (≧95%). In addition, the survey highlighted several practical considerations - including sample collection and fixation issues - that may help to preserve, and improve upon, current good practice. Conclusions: Overall, survey responses indicate nationwide adherence to recommended practice guidelines for HER2 testing in breast cancer, resulting in excellent inter-laboratory concordance.
- Subjects
CANADA; HER2 gene; BREAST cancer treatment; INTERNET surveys; AMERICAN Society of Clinical Oncology
- Publication
Canadian Journal of Pathology, 2013, Vol 5, Issue 1, p8
- ISSN
1918-915X
- Publication type
Article